Firefighters will train alongside Police Scotland and Scottish Ambulance Service colleagues within disused parts of the eight-storey building on Almada Street from 11am to 3pm on Sunday, October 28.
This will involve a significant presence around the former university building and surrounding area, with artificial smoke likely to be visible from a distance.
The exercise will involve more than 100 people, including emergency service workers and volunteers in role-play simulation.
Station Manager Barry Cranstoun said: “I’d like to remind the public that this is a controlled event, and not to be alarmed by the significant presence around the area on Sunday.
“Exercises such as this are important and hugely worthwhile for our firefighters to train to protect our communities alongside emergency service colleagues in a unique and dynamic environment – and follows several months of planning.
“It has also been made possible thanks to invaluable support from our partners in South Lanarkshire Council.
“I’d like to take this opportunity to thank the local authority, the University of West of Scotland, and our partners for their continued support, and also to the Salvation Army for offering to provide catering and refreshments for our crews and volunteers on the day.”